Research on Curcumin – the active ingredient of Curcuma Longa; Academic studies on Prostate Cancer, Alzheimer, Chemotherapy, Cancer Metastases, Diabetes, Ulcer, Hepatitis B, Infection Diseases, Antimicrobial, Sperm, Cataract Problem, Stress and Gall Bladder Problems…

  •  Curcumin and cancer; the fight of the perennial plant with living cells and cancer in the elders

kanserhucresiScientific studies on curcumin, derived from Curcuma Longa used for centuries in the treatment of various inflammations, come to a conclusion. Clinical studies show that curcumin helps regulating the structure of cell, prevents cell division and negative cell signals, thus positively affecting metastasis.It is also revealed that the activity of curcumin is effective on leukemia-lymphoma, gastrointestinal system cancers, genitourinary system cancers, breast cancer, ovarian cancer, head-neck cancer, lung cancer, melanoma, and neurologic cancers.

Preatha Anand.,Chitra Sundorom.,Sonio Jhuroni.,Ajaikumar B.,Bharat B.Aggarwal,in cancer letters. 2008,vol;267 (1)

  • Anti-carcinogenic drug effect of curcumin – an exotic spiceThese studies show that some side effects of traditional chemotherapy can be avoided by some phytochemicals in plants.

curcumin1In phase 1 clinical studies, it was found that curcumin, derived from Curcuma Longa, is beneficial and safe for the future and plays a therapeutic role in cancer types where the cell cycle deteriorates. In these phase studies, curcumin showed a therapeutic effect on various diseases in humans. It was revealed that curcumin is good for cancer, cardiovascular diseases, diabetes, arthritis and neurological diseases. It is found that curcumin, alone or combined, is beneficial, prevents physiological cell deaths (apoptosis) and enables the cell structure to maintain its physiological properties. According to the results of the preliminary examination, curcumin displays a significant activity in gastrointestinal system and colorectal cancers.

Gaurısankar Sa.,Tanya Das.,Shuvamay Bonerjee.,Division of Molekuler Medicine,Bose İnstıtute Ameen Journal Medicine Sciences,2010,vol;3

prostatThe effect of Curcuma Longa on prostate cancer by benefiting from its cytotoxic effect and protein profile The effect of Curcuma Longa extract, obtained from its dry powder and ethyl acetate, on metastatic prostate cancer was investigated. It was found that Curcuma Longa extract has a therapeutic effect on prostate cancer, since it provides protein level on DNA through its proteomic profile and cytotoxic effect and prevents uncontrolled division of proteins on cells.KurapatiV.K.Rao.,Nawsal M.Boukli.,Thangavel Samikkanu.,Luıs A.Cobano.College of Medicine Florida International University Miami, Florida 33199.,USA Open proteimi Journal.2011
antikanserAnti-carcinogenic effect of curcumin, derived from Curcuma Longa, on neck squamous cell carcinomaHead-neck squamous cell carcinoma is the sixth most common cancer type in the world. Its treatment is surgery, platinum-based chemotherapy and radiation oncology. These treatment methods have psychological and physical side effects on the patients; furthermore, they cause the formation of new illnesses.In vitro and in vivo studies show that curcumin reduces all side effects in such cancer types and even entirely eliminates in some cases. It is also found that it has a highly therapeutic effect.

Available By; Wilkan R.,Veena M.S.,Wang M.B., Srivatsan E.S., Molecular cancer (mol. cancer) 2011 Feb.07 vol;10 Journal article, Biomed central. 

alzheimerMemory strengthening activity and acetylcholinesterase (AChE) inhibitor activity of curcuminoidsCurcuma Longa is thought to be useful for Alzheimer. This study investigated curcumin and curcuminoids’ effect of inhibiting the acetylcholinesterase (AChE) enzyme and strengthening memory.In in vitro and in vivo studies, the memory strengthening effect of AChE inhibitor activity was investigated in experimental rats via Morris water maze. Curcuminoids have been found to have AChE inhibitor effect and memory strengthening effect. Consequently, it is stated that curcumin and curcuminoids derived from Curcuma Longa are useful in the treatment of Alzheimer.

Tauqeer Ahmed., Anwarrul Hassan.,Gilani, İn Pharmacology, Biochemistry and Behavior.,2009,91 (4) 

Alzheimer activity of curcumin and its derivativesOxidative stress induced by Beta-amyloid is a significant cause of neuronal death of cells in Alzheimer disease. It is expressed that, thanks to the antioxidant activity of three different curcumin analogues, Curcuma Longa protects cells against beta-amyloid effect, thus preventing the Alzheimer disease.

Kım D.,Park S.,Kım J., Neuroscience Letters, 2001,303;57-61

diabetInvestigation of antioxidant, anti-inflammatory, hypoglycemic and lipid-lowering effects of Curcuma Longa extractThis study explored the antioxidant, anti-inflammatory, hypoglycemic and lipid-lowering effects of Curcuma Longa extract.Living experimental subjects induced with high fat diet were divided into two groups and one of these groups was administered with a certain dose of extract. In the group to whom the extract was administered, it showed a strong inhibiting effect, with high radical scavenger effect arising from the antioxidant effect of Curcuma Longa, against the oxidation of LDL and glycation caused by fructose. Consequently, it is announced that the Curcuma Longa extract, thanks to its anti-oxidant activity, prevents glycation, lowers LDL, and thus reduces the risk of atherosclerosis.

S. Kubra.,I.Rattah.,Rao L.,Jagon Mohan., ‘Journal of food science’ Aug 2010 vol 75 

kanserStudies on antioxidant effect of curcumin and curcuminoidAntioxidant effects of curcuminoid, which is a natural polyphenol, have been tested on red blood cells and membranes of humans. It is found that curcumin prevents oxidative damage, thus providing benefit.

Grinberg L.N., Shalev O.,Tonnesen H.H.,Rachmilewitz E.A., ‘İnternational Journal of Pharmaceutics ‘ 1996,132; 251-257 

inflamasyonSynergic effect of curcumin and catechin on human cancerous cellsCurcumin, derived from the roots of Curcuma Longa, and catechin, a polyphenolic compound derived from green tea, were used together in this study. With their synergic anti-carcinogenic effect, curcumin and catechin prevented the growth of cancerous cells on colon and larynx cancers. Later it is explained that curcumin displays this effect by preventing the deformation and disintegration of DNA.

Manikanda,R.,Beulaja M.,Sellamuthu S.,Dinesh D.,Probhu D.,Babu G., Microscopy Research and Technique., Feb . 2012,Vol;75 

kolonInvestigation of antioxidant and anti-tumoral effects of curcuminIn clinical studies, it was found that curcumin, derived from Curcuma Longa, has antioxidant and anti-tumoral activities. Based on these activities, the experiments on human cancerous cells show and prove that curcumin prevents the spread and reproduction of colon cancer cells.

Valentina Basile., Erika Ferrari., Sandra Lazzori.,Silvia Belluti.,Carol Imbriana., In Biochemical Pharmacology., 2009 , 78(10) 

losemiAnti-carcinogenic effect of curcumin on human leukemia cellsAll clinical studies prove that curcumin is a promising anti-carcinogenic agent particularly on human leukemia cells. It is found that curcumin prevents the reproduction of these cells, thus reducing the risk of death.

Jie Chen., Guiying Wang.,Libing Wang.,Jiohang Kang., In European Journal of Pharmaceutical Sciences, 2010,41(2)., Department of Hematology. 

antikanserAnti-carcinogenic activity of curcumin on human chondrosarcoma cells (soft tissue tumor)This study explored the anti-carcinogenic effects of curcumin on human chondrosarcoma cells (cartilaginous soft tissue tumor). The curcumin extract was administered to different animals during 21 days and their results were investigated. When the collected data were analyzed, it was found that the size of tumors decreased 60%.Chondrosarcoma is known as a soft tissue tumor with a poor prognosis not responding to chemotherapy. This study proves that curcumin is a new anti-carcinogenic agent in the treatment of chondrosarcoma.

Hsiang-ping Lee.,Te-Mao Li., Jung- Ying Tsao.,Yi-C hın Fang., In International Immunopharmacology. June 2012, 13(2) 

safraCholagogue activity of the Curcuma Longa extractCholagogue activity is attributed to volatile oil’s and pigment’s stimulation of bile secretion.Sodium curcumin, when intravascularly administered to dogs in the dose of 24 mg/kg, doubled the rate of bile flow without any tangible disorders in blood pressure and respiration. In addition to its cholagogue effect, curcumin is said to stimulate the spasms of gallbladder muscle, that is, it enables gallbladder to be discharged. This substance has a very low toxicity.

Watt.J.M. Mrdicanal and poisonous Plants of Southern and Eastern Africa Eand S.Livingstne LTD. Edinburg and London 1962

unhappy redhead womanAnti-inflammatory effect of powdered Curcuma LongaPowdered and ground Curcuma Longa was combined with linden for an anti-inflammatory effect. Anti-inflammatory activity was controlled in various living experimental subjects and the found anti-inflammatory effect was emphasized to be as strong as cortisone in carrageenan oedema.

Mills S. Bone k., Principles and Practice of Phytoterapy modern herbal medicine, from British Library 2000, 569-580 

inflamasyonAnti-inflammatory effect of curcumin and derivatives on artery smooth muscle cells and phagocytesThe major complication of coronary stent placement is restenosis, and it is generally followed by smooth muscle cell reproduction and inflammatory reactions. Since curcumin has anti-inflammatory and anti-proliferative properties, it is anticipated that it may reduce the stent restenosis. To verify this, curcumin poly 1 lactic asid (C-PLLA) with curcumin-release PLLA (poly 1 lactic asid) films was produced, and its anti-inflammatory and anti-proliferative properties were tested in human coronary artery smooth muscle cells culture systems by using peritoneal phagocyte. It was observed that addition of curcumin reduces the phagocyte gathering and on C-PLLA films and its activation. Curcumin improved the effects of antioxidant, anti-inflammatory and anti-proliferative factors.Consequently, it is explained that curcumin displays this effect through the protein pathway activated with mitogen and it regulates the function of cells and genes.

Nyugen K.T.,Shaıkh N., Shukla K.P.,Su S.H.,Eberhart C.,Tang L., ‘ molecular responses of vascular smooth muscle cells and phagocytes to curcumineluting bioresorbable stent materials’ Biomaterials 2004, 25 5333-5346 

diabet2Investigation of the effect of Curcuma Longa extract on plasma glucose and insulinThe research was carried out on 14 healthy and voluntary people (7 males, 7 females). 6g Curcuma Longa extract was administered orally on certain days and insulin levels were checked on certain periods. It was observed that the postprandial insulin levels increased in this group to which Curcuma Longa extract was administered. Consequently, IT IS SCIENTIFICALLY EXPLAINED THAT THE CURCUMA LONGA EXTRACT HAS POSITIVE EFFECTS ON INSULIN RELEASE IN HUMANS.

Wickenberg J.,İngemansson SL.,Hlebowicz D., ‘ Nutrition Journal ‘ (Nutr. J.) oct.2010,12, ISSN ;1475-2891 

hepatitInvestigation of the effect of Curcuma Longa extract on Hepatitis B virusIt was analyzed whether Curcuma Longa, whose aqueous extract was prepared, had an antiviral activity against the replication of Hep G HBV on the cells containing HBV genomes. The extract suppressed the release of Hep G and Hbs AG on these cells, thus inhibiting the HBV replication, and also it suppressed the HBV production this way, thus making the HBV RNA levels normal. Besides, the Curcuma Longa extract did not form any toxic effect on liver cells. These data show that the Curcuma Longa extract increases the P53 protein level and suppresses the HBV replication, and that it can safely be used in liver diseases caused by HBV infection.

Hye Jin Kim., Hwa Seungyoo.,Yin Kim.,Mijee Kim.,Yaungsoo Kim.Jeang Keun ahn., ‘ In Journal of Etnopharmacy ‘ 2009.124(2) 

karacigerInvestigation of the effect of curcumin on rats on which liver inflammation and hyperplasia induced with diethylnitrosamineThis study proved by histopathologic examination that curcumin, orally administered to rats in doses of 200 mg/kg and 600 mg/kg, effectively suppressed liver inflammation and hyperplasia induced with diethylnitrosamine. It is known that the formation of hepatocellular carcinoma in humans is mostly related to viruses, bacteria and chemicals. The findings of this study show that CURCUMIN HAS A SIGNIFICANT ROLE in preventing hepatocellular carcinoma in humans.

Chuang S.,Cheng A.,Kuo J., ‘ Food and Chemical Toxicology ‘ 2000 , 38 ; 991-995 

diabetInvestigation of curcumin activity on rats which were not diabetic but turned into diabetic through streptozotocinThis study explored the effects of bis curcumin oxovanadium complex (BCOV) on blood glucose levels, serum lipid levels, blood pressure and vascular responsiveness in streptozotocin-induced rats, and they were compared with vanadyl sulphate. Consequently, this study reveals that BCOV regulates antidiabetic and hypolipidemic activity and cardiovascular complications caused by diabetes.

Majithıya J.B., Balaraman R.,Gırıdhar R.,Yadav M.R., ‘Journal of Trace Elements in Medicine and Biology’ 2005, 18; 211-217

kanserInvestigation of curcumin inhibitor effect on NF-kB activation and experimental steatohepatitis in miceOxidative stress is a determinant cause of steatohepatitis not related to alcohol, whereas the relation between oxidative stress and inflammatory accumulation needs to be proved. Its role in NF-kB and inflammatory accumulation was analyzed in experimental steatohepatitis. The mice were fed in such a way that they would suffer from methionine and choline deficiency (MCY), and controlled diets with and without curcumin were administered to them for four weeks. Curcumin reduced the severity of hepatitis inflammation in experimental steatohepatitis induced with curcumin+MCY diet.

Leclercq A.,Farrell G.C.,Sempoux C.,Pen A.,HorsmansY., ‘Curcumin inhibits NF-kB activation and reduced the severity of experimental steatohepatitis in mice ‘ Journal of Hepatology 2004, 41 

inflamasyonPotential therapeutic activity of Curcuma Longa extract against anti-inflammatory agentsRecent studies reveal that anti-inflammatory activity occurs due to curcumin (diferuloylmethane). It is shown that curcumin effectively alleviates inflammatory cases in most chronic diseases including neurodegenerative, cardiovascular, pulmonary, autoimmune, metabolic and neoplastic diseases.

Aggarwal, B.B., Harikumar,K.B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, The International Journal of Biochemistry & Cell Biology ,2009 ,41;40-59 

stresOxidative stress preventive effect of curcuminIn vitro and in vivo studies reveal that curcumin, a commonly used spice and food colorant, has anti-inflammatory, anti-tumoral and strong antioxidant properties. A study shows that curcuminin increases the activity of heme oxigenase 1 (HO-1) in vascular endothelial cells and is a strong inducer of HO-1, which has an important role in cell protection against oxidative stress.

Motterlini R., Foresti R., Bassi R., Green C., ‘ Free Radical Biology & Medicine’ 2000, vol 28 no 8 

kataraktInvestigation of the effects of curcumin on in vivo galactosemic cataract in ratsThe studies show that curcumin, derived from Curcuma Longa, alleviated the lens opacification induced with 4-Hydroxynonenal in organ culture. There is a relationship between oxidative stress and formation mechanism of galactosemic cataract. The studies were done to find out whether curcumin taken with foods would alleviate in vivo galactosemic cataract in rats. It was revealed that the lenses of rats fed with curcumin-supported galactose diet were cleaner than the ones fed only with galactose. The lens epithelium of the rats fed with galactose suffered from apoptosis (cell death), while this case was quite few in the rats fed with curcumin-supported galactose.These findings show that taking curcumin in low doses with foods prevents the formation of galactosemic cataract in rats and that curcumin can reduce the level of apoptosis in lens epithelium cells induced with galactose.

Pandya U.,Chandra A., Awasthi S., ‘ Nutrition Research ‘ 2000, vol,20 no;4 

spermIn vitro studies carried out to activate sperm with the Curcuma Longa extract74 infertile patients were divided into two groups according to their sperm parameters. A control group consisting of normal patients was also included. The Curcuma Longa extract was administered to these two groups in certain doses. The sperms were incubated in certain intervals for 30 minutes in 37 degree. Sperm concentration, motility, activity in classes, progressive motility, normal morphology and agglutination were evaluated. For both treatment groups, sperm parameters were better than the control group. It is said that the Curcuma Longa extract, used for pharmaceutical purposes in assisted reproductive techniques, is ideal for standardization.

Muhammad Baqir M.R., ‘Journal of Medical Sciences ‘2011, VOL; 9 

antimikropAntimicrobial activity turmeric (extract with ethanol)The extract of Curcuma Longa with ethanol was analyzed against antimicrobial microorganisms. It is revealed that the Curcuma Longa extract has a high antimicrobial and antifungal activity on Aspergillus oryzae and Fungi eukaryotes bacterias and fungus of the groups Escherischia coli, Staphylococcus aureus, Saccharomyces.

Falco,AS.,Martinez,WJ.,Revista Venezolana de cienciay tecnologia de Alimentos 2(1) Valencia asociacion RVCTA, ‘Journal Article’ 2011 ,85-93 

idraryoluAntimicrobial activity of Curcuma Longa on diabetics over 3 different nodules (IYE)The Curcuma Longa extract prepared with different solvents was incubated for 24 hours in 37 degrees, and it showed an antimicrobial activity on diabetic pathogens, particularly on bacteria causing urinary tract infection, by acting as an antibiotic.

Saleem, Mehvish.,Daniel,Betty.,Murli,K., ‘International Journal of Pharmacy, Pharmaceutical Sciences ‘ oct.2011 Vol;3 Issue 4 

lipidTherapeutic effect of curcumin on oxidative damage and lipid peroxidation caused by sodium arsenite in experiments on different organs of ratsIt was investigated whether curcumin had a therapeutic effect on oxidative damage and lipid peroxidation caused by sodium arsenite in different organs of rats.The animals were divided into four groups, and the first one was used as the control group. Curcumin (15 mg/kg), sodium arsenite (5 mg/kg) and curcumin with sodium arsenite were orally administered to the 2nd, 3rd and 4th groups for thirty days. It was found out that sodium arsenite alone increased thiobarbituric asid-reactive substances (TBARM) in plasma, liver, kidney, lung, testicles and brain. The content of sulfhydryl groups (SH groups) in plasma and tissues and the activities of glutation-S-transferase, superoxide dismutase and catalase (antioxidant enzymes) significantly decreased, compared with the control group. While the treatment with only curcumin reduced TBARM levels, the levels of SH – groups and antioxidant enzyme activities increased. TBARM levels decreased in the group to which curcumin was administered with sodium arsenite, and the level of SH – groups and antioxidant enzyme activities also decreased in small amounts.The results, compared with the control group, show that the treatment with sodium arsenite decreased the weight of the body and increased the weight of the liver. Curcumin administered with sodium arsenite reduces its toxic effects.

El-Demerdash F.M., Yousef M., Radwan, F.M.E., ‘ Food and Chemical Toxicology ‘ 2009, 47; 249-254 

Investigation of the effect of curcumin on oxidative liver damage and lipid peroxidation caused by cadmium in ratsThe effects of orally administered preliminary curcumin treatment (50 mg/kg a day and 3-day treatment) on oxidative liver damage and cadmium (Cd) chloride application (0.025 mmol/kg in rats and 0.03 mmol/kg in mice, s.c., an hour after the last curcumin treatment) were investigated in animal experiments. Lipid peroxidation level induced with cd in rats was significantly reduced with preliminary curcumin treatment. Lipid peroxidation induced with cd in mice was also eliminated with curcumin treatment.

Eybl V., Kotyzova D., Bludovska M., ‘ Toxicology letters ‘ 2004, 151; 79-85 

ulserFormation of gastric ulcer induced with indomethacin caused by reactive oxygen derivatives and investigation of gastroprotective effect of curcumin on thisCurcumin blocks the gastric lesions induced with indomethacin based on the dose and provides 82% protection in the dose of 25 mg/kg. It is found that the oxidative damage induced with indomethacin caused by reactive oxygen derivatives is prevented by curcumin. Curcumin prevents peroxidase depending on concentration and consumes H2O2 necessary for oxidation which is the substrate of peroxidase, thus blocking the indomethacin oxidation. It is stated that curcumin prevents the inactivation of indomethacin and peroxidase, removes H2O2 and derivatives, thus preventing gastric damage.

Chattopadhyay I., Bandyopadhyay U., Biswas K., Maity P., Banerjee R.K., ‘ Free Radical Biology & Medicine ‘ 2006 ,40; 1397-1408